Phenylpropanoids and polyketides
Medchemexpress LLC Fk-453 | 121524-18-3 | 99.2% | 375.46 g·mol⁻¹ | C23H25N3O2 | 100 MG
FK 453 is a potent, selective adenosine A1 receptor antagonist (IC50 = 17.2 nM) supplied as a high-purity small-molecule powder for research use. It includes recommended storage and solvent handling guidance to support reproducible in vitro assays.
- High purity 99.2%.
- Potent adenosine A1 receptor antagonist, IC50 17.2 nM.
- Molecular weight 375.46 g·mol⁻¹; formula C23H25N3O2.
- Recommended solvent DMSO at 100 mg/mL; may require ultrasonication.
- Storage: powder -20°C (up to 3 years), 4°C (up to 2 years); in solvent -80°C (6 months), -20°C (1 month).
- Suitable for in vitro pharmacology and receptor binding studies.
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 200mg
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Medchemexpress LLC N-(1-oxoheptyl)-D-gamma-glutamyl-(6R)-6-carboxy-L-lysyl-D-alanine | 79335-75-4 | 99.9% | 502.56 g/mol | C22H38N4O9 | 10mg
FK-565 is a nucleotide oligomerization domain-1 (NOD1) ligand FK-565 induces murine model with arteritis[1]